| Pair Name | Curcumin, Melphalan | ||
| Phytochemical Name | Curcumin (PubChem CID: 969516 ) | ||
| Anticancer drug Name | Melphalan (PubChem CID: 460612 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Curcumin, Melphalan | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | CASP3 | hsa836 |
| Up-regulation | Expression | CASP7 | hsa840 | |
| Up-regulation | Expression | CASP9 | hsa842 | |
| Up-regulation | Expression | CDKN1A | hsa1026 | |
| Down-regulation | Expression | TP53 | hsa7157 | |
| In Vitro Model | MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 |
| MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 | |
| MCF-10A | Healthy | Homo sapiens (Human) | CVCL_0598 | |
| Result | Curcumin and melphalan cotreatment induces cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells | |||
| No. | Title | Href |
|---|---|---|
| 1 | Curcumin and melphalan cotreatment induces cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells. Sci Rep. 2023 Aug 18;13(1):13446. doi: 10.1038/s41598-023-40535-5. | Click |
